Research Summary
Members
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Hongri Gong
professor gonghr@nankai.edu.cn
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Zhenwu Yu
postdoctor
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Yuying Zhang
doctoral student
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Yuezheng Lai
doctoral student
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Long Yu
doctoral student
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Jinxu Xu
doctoral student
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Ziyan Feng
doctoral student
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Ziqing Zhao
doctoral student
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Fusen Yang
doctoral student
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Yue Chen
doctoral student
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Jiliang Deng
doctoral student -
Yutong Liu
doctoral student
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Jianyun Wang
master student
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Kun Shi
master student
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Yuanyuan Zhou
master student
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Xiaoting Zhou
Ph.D. graduate
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Shan Zhou
Ph.D. graduate
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Weiwei Wang
Ph.D. graduate
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Zhanqiang Du
Ph.D. graduate
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Yanting Tang
Ph.D. graduate
Publications
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Tang Y#, Mu A#, Zhang Y, Zhou S, Wang W, Lia Y, Zhou X, Liu F, Yang X, Gong H*, Wang Q* & Rao Z
Cryo-EM structure of Mycobacterium smegmatis DyP-loaded encapsulin
Tuberculosis, caused by Mycobacterium tuberculosis, remains a major global public health problem. Deciphering the complex biology of M. tuberculosis will aid in the development of new therapeutics to combat this pathogen. Encapsulins, naturally encapsulatProc Natl Acad Sci USA | 2021-04-14 -
Zhou X#, Gao Y#, Wang W, Yang X, Yang X, Liu F, Tang Y, Lam SM, Shui G, Yu L, Tian C, Guddat LW, Wang Q*, Rao Z* & Gong H*
Architecture of the mycobacterial succinate dehydrogenase with membrane-embedded Rieske FeS cluster
Targeting energy metabolism in Mycobacterium tuberculosis has emerged as a new paradigm in antituberculosis drug discovery. Succinate dehydrogenase is considered the regulator of respiration in M. tuberculosis. Mycobacteria contains two different succinatProc Natl Acad Sci USA | 2021-04-05 -
Gong H#*, Gao Y#, Zhou X, Xiao Y, Wang W, Tang Y, Zhou S, Zhang Y, Ji W, Yu L, Tian C, Lam SM, Shui G, Guddat LW, Wong L-L, Wang Q* & Rao Z*
Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF
Diheme-containing succinate:menaquinone oxidoreductases (Sdh) are widespread in Grampositive bacteria but little is known about the catalytic mechanisms they employ for succinate oxidation by menaquinone. Here, we present the 2.8 Å cryo-electron microscNat Commun | 2020-08-25 -
Gong H#, Li J#, Xu A#, Tang Y, Ji W, Gao R, Wang S, Yu L, Tian C, Li J, Yen H-Y, Lam SM, Shui G, Yang X, Sun Y, Li X, Jia M, Yang C, Jiang B, Lou Z, Robinson CV, Wong L-L, Guddat LW, Sun F*, Wang Q* & Rao Z*
An electron transfer path connects subunits of a mycobacterial respiratory supercomplex
This study of a respiratory supercomplex in Mycobacteria reveals cofactors positioned at distances that permit electron tunneling, enabling direct intrasupercomplex electron transfer from menaquinol to oxygen without the need for a separate cytochromScience | 2018-10-03
