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Wang L, Wen M, Cao X
Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses
DNA viruses typically eject genomic DNA into the nuclei of host cells after entry. It is unclear, however, how nuclear pathogen-derived DNA triggers innate immune responses. We report that heterogeneous nuclear ribonucleoprotein A2B1 ( …
Science | 2022-02-27
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Tu J, Huo Z, Liu Y, Jin W, Chen YH, Xu Y, Chen SH, Rainusso N, Berg NK, Bazer DA, Vellano C, Jones P, Eltzschig HK, Zhao Z, Kaipparettu BA, Zhao R, Wang LL, Lee DF
Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome
RTS osteoblast metabolic assays demonstrated elevated mitochondrial respiratory complex I function, increased oxidative phosphorylation (OXPHOS), and increased ATP production. Inhibition of mitochondrial respiratory complex I activity by IACS-010759 selectively suppressed …
PLoS Genet | 2022-01-16
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Xue D, Xu Y, Kyani A, Roy J, Dai L, Sun D, Neamati N
Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors
Inhibition of oxidative phosphorylation (OXPHOS) is a promising therapeutic strategy for select cancers that are dependent on aerobic metabolism. Here, we report the discovery, optimization, and structure-activity relationship (SAR) study of a series of novel OXPHOS …
J Med Chem | 2022-01-16
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Yin M, O'Neill LAJ.
The role of the electron transport chain in immunity
The electron transport chain (ETC) couples oxidative phosphorylation (OXPHOS) with ATP synthase to drive the generation of ATP. ...Complex I has been shown to generate reactive oxygen species (ROS), with key roles identified in inflammatory macrophages and T
FASEB J | 2021-12-16
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Surace L, Doisne JM, Croft CA, Thaller A, Escoll P, Marie S, Petrosemoli N, Guillemot V, Dardalhon V, Topazio D, Cama A, Buchrieser C, Taylor N, Amit I, Musumeci O, Di Santo JP.
Dichotomous metabolic networks govern human ILC2 proliferation and function
Here, we show that circulating naive ILC2s have an unexpected metabolic profile with a higher level of oxidative phosphorylation (OXPHOS) than natural killer (NK) cells. Accordingly, ILC2s are severely reduced in individuals with mitochondrial disease
Nat Immunol | 2021-12-08
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Xu Y, Erdjument-Bromage H, Phoon CKL, Neubert TA, Ren M, Schlame M
Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane
In yeast, the concentration of proteins involved in oxidative phosphorylation (OXPHOS) correlated with the cardiolipin composition. Genetic ablation of either remodeling or biosynthesis of cardiolipin caused a substantial drop in the surface density of OX
EMBO J | 2021-12-08