-
Patro S, Ratna S, Yamamoto HA, Ebenezer AT, Ferguson DS, Kaur A, McIntyre BC, Snow R, Solesio ME
ATP Synthase and Mitochondrial Bioenergetics Dysfunction in Alzheimer's Disease
In fact, in mammals, including humans, the main source of cellular ATP is the oxidative phosphorylation (OXPHOS), a process that occurs in the mitochondrial electron transfer chain (ETC). ...
Int J Mol Sci | 2021-12-08
-
Surace L, Doisne JM, Croft CA, Thaller A, Escoll P, Marie S, Petrosemoli N, Guillemot V, Dardalhon V, Topazio D, Cama A, Buchrieser C, Taylor N, Amit I, Musumeci O, Di Santo JP.
Dichotomous metabolic networks govern human ILC2 proliferation and function
Here, we show that circulating naive ILC2s have an unexpected metabolic profile with a higher level of oxidative phosphorylation (OXPHOS) than natural killer (NK) cells. Accordingly, ILC2s are severely reduced in individuals with mitochondrial disease
Nat Immunol | 2021-12-08
-
Rieger B, Arroum T, Borowski MT, Villalta J, Busch KB.
Mitochondrial F1 FO ATP synthase determines the local proton motive force at cristae rims
Our results clearly show that ATP synthase activity substantially controls the PMF and that IF1 is essential under OXPHOS conditions to prevent reverse ATP synthase activity due to an almost negligible deltapH. .
EMBO Rep | 2021-12-08
-
Subrahmanian N, LaVoie MJ
Is there a special relationship between complex I activity and nigral neuronal loss in Parkinson's disease? A critical reappraisal
Parkinson s disease (PD) is a progressive neurodegenerative disease manifesting both motor and non-motor symptoms. ...Consisting of more than 40 subunits, complex I is the first enzyme of the electron transport chain that is required for mitochondrial …
Brain Res | 2021-12-08
-
Wang M, Chan EWC, Wan Y, Wong MH, Chen S.
Active maintenance of proton motive force mediates starvation-induced bacterial antibiotic tolerance in Escherichia coli.
Eradication of tolerant sub-population could be achieved by disruption of PMF using the ionophore CCCP, or through suppression of PMF maintenance mechanisms by simultaneous inhibition of the phage shock protein (Psp) response and electron transport chain
Commun Biol | 2021-12-08
-
Li J, Han L, Vallese F, Ding Z, Choi SK, Hong S, Luo Y, Liu B, Chan CK, Tajkhorshid E, Zhu J, Clarke O, Zhang K, Gennis R.
Cryo-EM structures of Escherichia coli cytochrome bo 3 reveal bound phospholipids and ubiquinone-8 in a dynamic substrate binding site
Quinol oxidases that are members of the heme–copper superfamily of respiratory oxygen reductases have evolved from cytochrome c oxidases. They directly oxidize quinol and reduce oxygen to water. Here, we describe two high-resolution cryogenic electron mic
Proc Natl Acad Sci U S A | 2021-12-08