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Brzezinski P, Moe A, Ädelroth P
Structure and Mechanism of Respiratory III-IV Supercomplexes in Bioenergetic Membranes
In the final steps of energy conservation in aerobic organisms, free energy from electron transfer through the respiratory chain is transduced into a proton electrochemical gradient across a membrane. ...These complexes function independently, but in many
Chem Rev | 2021-12-08
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Jourdain A A, Begg B E, Mick E, et al.
Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS
Expression of LUC7L2 and the U1 snRNP represses OXPHOS
Pre-mRNA splicing and expression of PFKM and SLC7A11 (xCT) requires LUC7L2
Loss of LUC7L2 and glycolysis promotes respiratory chain (super)complex assembly
LUC7 family members cross-regulate each o
Molecular Cell | 2021-12-08
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Nelson MA, McLaughlin KL, Hagen JT, Coalson HS, Schmidt C, Kassai M, Kew KA, McClung JM, Neufer PD, Brophy P, Vohra NA, Liles D, Cabot MC, Fisher-Wellman KH.
Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia
Together, these findings argue against ATP being the primary output of leukemic mitochondria and provide proof-of-principle that restoring, rather than disrupting, OXPHOS may represent an untapped therapeutic avenue for combatting hematological malignancy
Elife | 2021-12-08
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Hung-Jen Shih, Chao-Yuan Chang, I-Tao Huang, Pei-Shan Tsai, Chia-Li Han, Chun-Jen Huang
Testicular torsion-detorsion causes dysfunction of mitochondrial oxidative phosphorylation
Testicular TD produced mitochondria injury and dysregulation of mitochondrial OXPHOS in ipsilateral twisted testes. Different protein expressions were identified in the mitochondrial OXPHOS complexes with testicular TD; new therapeutic targets may be iden
Andrology | 2021-12-08
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Raggi C, Taddei ML, Sacco E, Navari N, Correnti M, Piombanti B, Pastore M, Campani C, Pranzini E, Iorio J, Lori G, Lottini T, Peano C, Cibella J, Lewinska M, Andersen JB, di Tommaso L, Viganò L, Di Maira G, Madiai S, Ramazzotti M, Orlandi I, Arcangeli A,
Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma.
Little is known about the metabolic regulation of cancer stem cells (CSCs) in cholangiocarcinoma (CCA). We analyzed whether mitochondrial-dependent metabolism and related signaling pathways contribute to stemness in CCA.
J Hepatol | 2021-12-08
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Chen D, Wang Y, Manakkat Vijay GK, Fu S, Nash CW, Xu D, He D, Salomonis N, Singh H, Xu H.
Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation
We propose that elevated OXPHOS activity promotes B cell clonal expansion and also positive selection by tuning cell division times.
Nat Immunol | 2021-12-08