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Ortiz SC, Huang M, Hull CM.
Discovery of Fungus-Specific Targets and Inhibitors Using Chemical Phenotyping of Pathogenic Spore Germination
There is a critical need for new antifungal drugs; however, the lack of available fungus-specific targets is a m...
mBio | 2021-12-08
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Betsinger CN, Jankowski CSR, Hofstadter WA, Federspiel JD, Otter CJ, Jean Beltran PM, Cristea IM.
The human cytomegalovirus protein pUL13 targets mitochondrial cristae architecture to increase cellular respiration during infection
We demonstrate that pUL13 forms temporally tuned interactions with the mitochondrial contact site and cristae organizing system (MICOS) complex, a critical regulator of cristae architecture and electron transport chain (ETC) function. Stimulated emission
Proc Natl Acad Sci U S A | 2021-12-08
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Wang H, Zhang H, Wang Y, Brown ZJ, Xia Y, Huang Z, Shen C, Hu Z, Beane J, Ansa-Addo EA, Huang H, Tian D, Tsung A.
Regulatory T cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis
RNA-seq data reveals that NETs impact gene profiles in naive CD4(+) T cells and tilt the balance toward Tregs with most differential differentially expressed genes enriched in mitochondrial oxidative phosphorylation (OXPHOS). NETs through facilitating mit
J Hepatol | 2021-12-08
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Chicano TM, Dietrich L, de Almeida NM, Akram M, Hartmann E, Leidreiter F, Leopoldus D, Mueller M, Sánchez R, Nuijten GHL, Reimann J, Seifert KA, Schlichting I, van Niftrik L, Jetten MSM, Dietl A, Kartal B, Parey K, Barends TRM
Structural and functional characterization of the intracellular filament-forming nitrite oxidoreductase multiprotein complex.
Nitrate is an abundant nutrient and electron acceptor throughout Earth s biosphere. Virtually all nitrate in nature is produced by the oxidation of nitrite by the nitrite oxidoreductase (NXR) multiprotein complex. ...The results also reveal unexpected fe
Nat Microbiol | 2021-12-08
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He J, Shangguan X, Zhou W, Cao Y, Zheng Q, Tu J, Hu G, Liang Z, Jiang C, Deng L, Wang S, Yang W, Zuo Y, Ma J, Cai R, Chen Y, Fan Q, Dong B, Xue W, Tan H, Qi Y, Gu J, Su B, Eugene Chin Y, Chen G, Wang Q, Wang T, Cheng J
Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development.
SENP1-Sirt3 signalling augments the deacetylase activity of Sirt3, promoting both OXPHOS and mitochondrial fusion. Mechanistically, SENP1 activates Sirt3 deacetylase activity in T cell mitochondria, leading to reduction of the acetylation of mitochondrial
Nat Commun | 2021-12-08
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Anderson NM, Qin X, Finan JM, Lam A, Athoe J, Missiaen R, Skuli N, Kennedy A, Saini AS, Tao T, Zhu S, Nissim I, Look AT, Qing G, Simon MC, Feng H
Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma
However, DLST loss significantly suppressed NADH production and impaired OXPHOS, leading to growth arrest and apoptosis of neuroblastoma cells. ...Together, these results demonstrate that DLST promotes neuroblastoma aggression and unveils OXPHOS as an ess
Cancer Res | 2021-12-08