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Sighel, D., Notarangelo, M., Aibara, S., Re, A., Ricci, G., Guida, M., ... & Quattrone, A.
Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth
Glioblastoma stem cells (GSCs) resist current glioblastoma (GBM) therapies. GSCs rely highly on oxidative phosphorylation (OXPHOS), whose function requires mitochondrial translation. Here we explore the therapeutic potential of targeting mitochondrial tra
Cell Reports | 2021-12-08
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Molina, J. R., Sun, Y., Protopopova, M., Gera, S., Bandi, M., Bristow, C., ... & Marszalek, J. R.
An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued opportunity in discovery of oncology drugs. Extensive efforts have focused on therapeutic targeting of glycolysis, whereas drugging mitochondrial oxidative phosphoryla
Nature Medicine | 2021-12-08
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Nuevo-Tapioles, C., Santacatterina, F., Stamatakis, K., de Arenas, C. N., ...& Cuezva, J. M.
Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
Mitochondrial metabolism has emerged as a promising target against the mechanisms of tumor growth. Herein, we have screened an FDA-approved library to identify drugs that inhibit mitochondrial respiration.
Nature Communications | 2021-12-08
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Morciano, G., Pedriali, G., Bonora, M., Pavasini, R., Mikus, E., Calvi, S., ... & Pinton, P.
A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients
G87E of ATP synthase subunit c is harmful under stressful conditions in humans
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G87E increases PTPC opening
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G87E worsens hypoxia reoxygenation damage in STEMI patients
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PTPC opening is positively related to reperfusion injury in STEMI pati
Cell Reports | 2021-12-08
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Spikes, T. E., Montgomery, M. G., & Walker, J. E.
Interface mobility between monomers in dimeric bovine ATP synthase participates in the ultrastructure of inner mitochondrial membranes
Mitochondria are the powerhouses of eukaryotic cells. Pairs of molecular machines with a rotary action, called ATP synthase, are embedded in their inner membranes and produce adenosine triphosphate, ATP, the fuel of life. These dimers form long rows on cr
Proc Natl Acad Sci USA | 2021-12-08
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Masoud, R., Reyes-Castellanos, G., Lac, S., Garcia, J., Dou, S., Shintu, L., ... & Carrier, A.
Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer
Mitochondrial respiration (oxidative phosphorylation, OXPHOS) is an emerging target in currently refractory cancers such as pancreatic ductal adenocarcinoma (PDAC)
Cell Reports Medicine | 2021-12-08