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Stoldt, S., Wenzel, D., Kehrein, K., Riedel, D., Ott, M., & Jakobs, S.
Spatial orchestration of mitochondrial translation and OXPHOS complex assembly
OXPHOS complex assembly is spatially well orchestrated, probably representing an unappreciated regulatory layer in mitochondrial biogenesisNature Cell Biology | 2021-12-08
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Shin, B., Benavides, G. A., Geng, J., Koralov, S. B., Hu, H., Darley-Usmar, V. M., & Harrington, L. E.
Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Reg
Our data reveal a regulatory role of mitochondrial OXPHOS in dictating the fate decision between Th17 and Treg cells by supporting early molecular events necessary for Th17 commitmentCell Reports | 2021-12-08
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Bonnay, F., Veloso, A., Steinmann, V., Köcher, T., Abdusselamoglu, M. D., Bajaj, S., ... & Knoblich, J. A.
Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis
Metabolic reprogramming is a key feature of many cancers, but how and when it contributes to tumorigenesis remains unclear Our work establishes a unique connection between cellular metabolism and immortalization of tumor-initiating cellsCell | 2021-12-08
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Guerrero-Castillo S, van Strien J, Brandt U, Arnold S
Ablation of mitochondrial DNA results in widespread remodeling of the mitochondrial complexome.
Human ρ0 cells devoid of mitochondrial DNA are viable despite being incapable of aerobic ATP synthesis. Complexome profiling analysis of ρ0 mitochondria provides insights how human cells can survive without respiration by reorganizing their mitochondrialEMBO J | 2021-12-07