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Masatoshi Murai, Hideto Miyoshi
Current topics on inhibitors of respiratory complex I
Recent X-ray crystallographic structural models of entire complex I may be helpful to carefully interpret this data. We herein focused on recent hot topics on complex I inhibitors and the subjects closely connected to these inhibitors, which may provide u
Biochimica et Biophysica Acta | 2021-12-08
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Thomas LW, Esposito C, Morgan RE, Price S, Young J, Williams SP, Maddalena LA, McDermott U, Ashcroft M.
Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia
Mitochondria are typically essential for the viability of eukaryotic cells, and utilize oxygen and nutrients (e.g. glucose) to perform key metabolic functions that maintain energetic homeostasis and support proliferation. Here we provide a comprehensive f
Commun Biol | 2021-12-08
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Chen, C., McDonald, D., Blain, A., Sachdeva, A., Bone, L., Smith, A. L., ... & Reeve, A. K.
Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson’s disease
Here we report the application of a mass spectrometry-based technology, imaging mass cytometry, to perform in-depth proteomic profiling of mitochondrial complexes in single neurons, using metal-conjugated antibodies to label post-mortem human midbrain sec
npj Parkinson's Disease | 2021-12-08
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Hornburg, Milena et al.
Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer
OXPHOS and IFN gene sets are enriched in infiltrated and excluded tumor cells.
Cancer Cell | 2021-12-08
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Hoskins, Aaron A. et al.
When cells are down on their LUC7L2, alternative splicing rewires metabolism for OXPHOS
Daniels et al., 2021 and Jourdain et al., 2021 identify LUC7L2 as a component of the U1 snRNP capable of reprogramming cellular metabolism through changes in alternative pre-mRNA splicing
Molecular Cell | 2021-12-08
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Formosa, L. E., Reljic, B., Sharpe, A. J., Hock, D. H., Muellner-Wong, L., Stroud, D. A., & Ryan, M. T.
Optic atrophy–associated TMEM126A is an assembly factor for the ND4-module of mitochondrial complex I
Mitochondria are critical organelles that play a central role in energy conversion in cells. Mutations in genes encoding mitochondrial proteins can lead to disease. Here, we discover that the optic atrophy–associated mitochondrial disease gene TMEM126A pl
Proc Natl Acad Sci USA | 2021-12-08